At least 22 civilians, including nine children, were killed when an UNRWA clinic sheltering displaced people was struck by an Israeli airstrike in the Jabalia camp north of the besieged Palestinian territory.
Gaza Civil Defense spokesman Mahmud Bassal said dozens of people were wounded in the strike, which "targeted the UNRWA building housing a medical clinic."
The Palestinian foreign ministry condemned the "massacre at the UNRWA clinic in Jabalia," calling for "serious international pressure" to halt Israel's widening offensive.
The Islamic Jihad resistance group has called the bombing a "blatant war crime."
Israel has, on several occasions, conducted strikes on UNRWA buildings housing displaced people in Gaza, where fighting has raged for most of the past 18 months.
A strike on the United Nations-run al-Jawni school in central Gaza on September 11 drew international outcry after the UN agency for Palestinian refugees said six of its staff were among the 18 people reported killed.
Separately, an airstrike in the southern city of Khan Yunis also claimed the lives of at least 13 Palestinians, including a child, and left several others injured.
The situation in the southern city of Rafah has also deteriorated, with intensified airstrikes and artillery shelling killing at least five people.
Meanwhile, the Israeli minister of military affairs, Israel Katz, announced plans to expand the military's ground offensive in Gaza, aiming to seize large areas to be added to the so-called buffer zones in the Strip.
Israel resumed the war on the Palestinian territory on March 18 in violation of the Gaza ceasefire.
The renewed aggression has killed over one thousand Palestinians. The overall toll from the genocide in Gaza has topped 50,420.
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